The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice

• Main Authors: Sagen Zac-Varghese (Author), Stefan Trapp (Author), Paul Richards (Author), Sophie Sayers (Author), Gao Sun (Author), Stephen R. Bloom (Author), Frank Reimann (Author), Fiona M. Gribble (Author), Guy A. Rutter (Author)
• Format: Book
• Published: The Company of Biologists, 2014-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Liver kinase B1 (LKB1; also known as STK11) is a serine/threonine kinase and tumour suppressor that is mutated in Peutz-Jeghers syndrome (PJS), a premalignant syndrome associated with the development of gastrointestinal polyps. Proglucagon-expressing enteroendocrine cells are involved in the control...