The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice

• Glavni autori: Sagen Zac-Varghese (Autor), Stefan Trapp (Autor), Paul Richards (Autor), Sophie Sayers (Autor), Gao Sun (Autor), Stephen R. Bloom (Autor), Frank Reimann (Autor), Fiona M. Gribble (Autor), Guy A. Rutter (Autor)
• Format: Knjiga
• Izdano: The Company of Biologists, 2014-11-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Liver kinase B1 (LKB1; also known as STK11) is a serine/threonine kinase and tumour suppressor that is mutated in Peutz-Jeghers syndrome (PJS), a premalignant syndrome associated with the development of gastrointestinal polyps. Proglucagon-expressing enteroendocrine cells are involved in the control...