Hirsutine ameliorates hepatic and cardiac insulin resistance in high-fat diet-induced diabetic mice and in vitro models

• Main Authors: Wei Hu (Author), Meng Li (Author), Wuyi Sun (Author), Qixiu Li (Author), Haiyan Xi (Author), Yuanye Qiu (Author), Ran Wang (Author), Qian Ding (Author), Zhou Wang (Author), Yue Yu (Author), Heping Lei (Author), Yicheng Mao (Author), Yi Zhun Zhu (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Closely associated with type 2 diabetes mellitus (T2DM), hepatic steatosis and cardiac hypertrophy resulting from chronic excess intake can exacerbate insulin resistance (IR). The current study aims to investigate the pharmacological effects of hirsutine, one indole alkaloid isolated from Uncaria rh...