Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver disease

• Main Authors: Christian Baumeier (Author), Luisa Schlüter (Author), Sophie Saussenthaler (Author), Thomas Laeger (Author), Maria Rödiger (Author), Stella Amelie Alaze (Author), Louise Fritsche (Author), Hans-Ulrich Häring (Author), Norbert Stefan (Author), Andreas Fritsche (Author), Robert Wolfgang Schwenk (Author), Annette Schürmann (Author)
• Format: Book
• Published: Elsevier, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Increased hepatic expression of dipeptidyl peptidase 4 (DPP4) is associated with non-alcoholic fatty liver disease (NAFLD). Whether this is causative for the development of NAFLD is not yet clarified. Here we investigate the effect of hepatic DPP4 overexpression on the development of live...