Adjuvant Antitumor Immunity Contributes to the Overall Antitumor Effect of Pegylated Liposomal Doxorubicin (Doxil^®) in C26 Tumor-Bearing Immunocompetent Mice

• Main Authors: Takuma Takayama (Author), Taro Shimizu (Author), Amr S. Abu Lila (Author), Yuki Kanazawa (Author), Hidenori Ando (Author), Yu Ishima (Author), Tatsuhiro Ishida (Author)
• Format: Book
• Published: MDPI AG, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Doxorubicin (DXR) has been reported to have direct cytotoxicity against cancer cells and indirect immunotoxicity by modulation of host antitumor immunity. Hence, it may prevent cancer progression by a dual mechanism. Doxil^®, a formulation of DXR encapsulated in polyethylene gl...