Investigation of possible solubility and dissolution advantages of cocrystals, I: Aqueous solubility and dissolution rates of ketoconazole and its cocrystals as functions of pH

• Hauptverfasser: Jaydip M. Vasoya (Verfasst von), Ankita V. Shah (Verfasst von), Abu T.M. Serajuddin (Verfasst von)
• Format: Buch
• Veröffentlicht: International Association of Physical Chemists (IAPC), 2019-04-01T00:00:00Z.
• Schlagworte: article
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Since there are conflicting reports in the literature on solubility and dissolution advantages of cocrystals over free forms, we systematically studied solubility and intrinsic dissolution rates of a weakly basic drug, ketoconazole, and its cocrystals with fumaric acid and succinic acid as functions...