Improving the solubility, activity, and stability of reteplase using in silico design of new variants

Reteplase (recombinant plasminogen activator, r-PA) is a thrombolytic agent recombined from tissue-type plasminogen activator (t-PA), which has several prominent features such as strong thrombolytic ability and E. coli expressibility. Despite these outstanding features, it demonstrates reduced fibri...

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Main Authors: Hooria Seyedhosseini Ghaheh (Author), Mohamad Reza Ganjalikhany (Author), Parichehreh Yaghmaei (Author), Morteza Pourfarzam (Author), Hamid Mir Mohammad Sadeghi (Author)
Format: Book
Published: Wolters Kluwer Medknow Publications, 2019-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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