Improving the solubility, activity, and stability of reteplase using in silico design of new variants

• Główni autorzy: Hooria Seyedhosseini Ghaheh (Autor), Mohamad Reza Ganjalikhany (Autor), Parichehreh Yaghmaei (Autor), Morteza Pourfarzam (Autor), Hamid Mir Mohammad Sadeghi (Autor)
• Format: Książka
• Wydane: Wolters Kluwer Medknow Publications, 2019-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Reteplase (recombinant plasminogen activator, r-PA) is a thrombolytic agent recombined from tissue-type plasminogen activator (t-PA), which has several prominent features such as strong thrombolytic ability and E. coli expressibility. Despite these outstanding features, it demonstrates reduced fibri...