Improving the solubility, activity, and stability of reteplase using in silico design of new variants

• Main Authors: Hooria Seyedhosseini Ghaheh (Author), Mohamad Reza Ganjalikhany (Author), Parichehreh Yaghmaei (Author), Morteza Pourfarzam (Author), Hamid Mir Mohammad Sadeghi (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Reteplase (recombinant plasminogen activator, r-PA) is a thrombolytic agent recombined from tissue-type plasminogen activator (t-PA), which has several prominent features such as strong thrombolytic ability and E. coli expressibility. Despite these outstanding features, it demonstrates reduced fibri...