Indole-3-Carbinol Stabilizes p53 to Induce miR-34a, Which Targets LDHA to Block Aerobic Glycolysis in Liver Cancer Cells

• Asıl Yazarlar: Yuehua Qi (Yazar), Chunjing Zhang (Yazar), Di Wu (Yazar), Yue Zhang (Yazar), Yunfeng Zhao (Yazar), Wenjuan Li (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2022-10-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Certain cancer cells prefer aerobic glycolysis rather than oxidative phosphorylation for energy supply. Lactate dehydrogenase A (LDHA) catalyzes the reduction of pyruvate to lactate and regains NAD+ so that glycolysis is continued. As a pivotal enzyme to promote smooth glycolysis, LDHA plays an impo...