Indole-3-Carbinol Stabilizes p53 to Induce miR-34a, Which Targets LDHA to Block Aerobic Glycolysis in Liver Cancer Cells

• Päätekijät: Yuehua Qi (Tekijä), Chunjing Zhang (Tekijä), Di Wu (Tekijä), Yue Zhang (Tekijä), Yunfeng Zhao (Tekijä), Wenjuan Li (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2022-10-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Certain cancer cells prefer aerobic glycolysis rather than oxidative phosphorylation for energy supply. Lactate dehydrogenase A (LDHA) catalyzes the reduction of pyruvate to lactate and regains NAD+ so that glycolysis is continued. As a pivotal enzyme to promote smooth glycolysis, LDHA plays an impo...