Discovery of novel spike/ACE2 inhibitory macrocycles using in silico reinforcement learning

• मुख्य लेखकों: Lev Shapira (लेखक), Shaul Lerner (लेखक), Guila Assayag (लेखक), Alexandra Vardi (लेखक), Dikla Haham (लेखक), Gideon Bar (लेखक), Vicky Fidelsky Kozokaro (लेखक), Maayan Elias Robicsek (लेखक), Immanuel Lerner (लेखक), Amit Michaeli (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Introduction: The COVID-19 pandemic has cast a heavy toll in human lives and global economics. COVID-19 is caused by the SARS-CoV-2 virus, which infects cells via its spike protein binding human ACE2.Methods: To discover potential inhibitory peptidomimetic macrocycles for the spike/ACE2 complex we d...