WTAP-mediated m6A modification of TRIM22 promotes diabetic nephropathy by inducing mitochondrial dysfunction via ubiquitination of OPA1

• Autores principales: Zeng Zhang (Autor), Fengzhu Zhou (Autor), Min Lu (Autor), Duanchun Zhang (Autor), Xinyi Zhang (Autor), Siyu Xu (Autor), Yanming He (Autor)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Objectives Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes and is the most common cause of end-stage renal disease. Tripartite motif-containing (TRIM) proteins are a large family of E3 ubiquitin ligases that contribute to protein quality control by regula...