Assessment of the FRET-based Teen sensor to monitor ERK activation changes preceding morphological defects in a RASopathy zebrafish model and phenotypic rescue by MEK inhibitor

• Main Authors: Giulia Fasano (Author), Stefania Petrini (Author), Valeria Bonavolontà (Author), Graziamaria Paradisi (Author), Catia Pedalino (Author), Marco Tartaglia (Author), Antonella Lauri (Author)
• Format: Book
• Published: BMC, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background RASopathies are genetic syndromes affecting development and having variable cancer predisposition. These disorders are clinically related and are caused by germline mutations affecting key players and regulators of the RAS-MAPK signaling pathway generally leading to an upregulate...