Kaurenoic Acid Possesses Leishmanicidal Activity by Triggering a NLRP12/IL-1β/cNOS/NO Pathway

• Main Authors: Milena Menegazzo Miranda (Author), Carolina Panis (Author), Suelen Santos da Silva (Author), Juliana Aparecida Macri (Author), Natalia Yoshie Kawakami (Author), Thiago Hideki Hayashida (Author), Tiago Bervelieri Madeira (Author), Vinicius Ricardo Acquaro (Author), Suzana Lucy Nixdorf (Author), Luciana Pizzatti (Author), Sérgio Ricardo Ambrósio (Author), Rubens Cecchini (Author), Nilton Syogo Arakawa (Author), Waldiceu Aparecido Verri (Author), Ivete Conchon Costa (Author), Wander Rogério Pavanelli (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leishmania amazonensis (L. amazonensis) infection can cause severe local and diffuse injuries in humans, a condition clinically known as American cutaneous leishmaniasis (ACL). Currently, the therapeutic approach for ACL is based on Glucantime, which shows high toxicity and poor effectiveness. There...