Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction

• Main Authors: Natasha Fillmore (Author), Jody L. Levasseur (Author), Arata Fukushima (Author), Cory S. Wagg (Author), Wei Wang (Author), Jason R. B. Dyck (Author), Gary D. Lopaschuk (Author)
• Format: Book
• Published: BMC, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Alterations in cardiac energy metabolism contribute to the development and severity of heart failure (HF). In severe HF, overall mitochondrial oxidative metabolism is significantly decreased resulting in a reduced energy reserve. However, despite the high prevalence of HF with pr...