Carajurin Induces Apoptosis in <i>Leishmania amazonensis</i> Promastigotes through Reactive Oxygen Species Production and Mitochondrial Dysfunction

• Ngā kaituhi matua: João Victor Silva-Silva (Author), Carla J. Moragas-Tellis (Author), Maria S. S. Chagas (Author), Paulo Victor R. Souza (Author), Davyson L. Moreira (Author), Daiana J. Hardoim (Author), Noemi N. Taniwaki (Author), Vanessa F. A. Costa (Author), Alvaro L. Bertho (Author), Daniela Brondani (Author), Eduardo Zapp (Author), Aldo Sena de Oliveira (Author), Kátia S. Calabrese (Author), Maria D. Behrens (Author), Fernando Almeida-Souza (Author)
• Hōputu: Pukapuka
• I whakaputaina: MDPI AG, 2022-03-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Carajurin is the main constituent of <i>Arrabidaea chica</i> species with reported anti-<i>Leishmania</i> activity. However, its mechanism of action has not been described. This study investigated the mechanisms of action of carajurin against promastigote forms of <i>Le...