Carajurin Induces Apoptosis in <i>Leishmania amazonensis</i> Promastigotes through Reactive Oxygen Species Production and Mitochondrial Dysfunction

• Main Authors: João Victor Silva-Silva (Author), Carla J. Moragas-Tellis (Author), Maria S. S. Chagas (Author), Paulo Victor R. Souza (Author), Davyson L. Moreira (Author), Daiana J. Hardoim (Author), Noemi N. Taniwaki (Author), Vanessa F. A. Costa (Author), Alvaro L. Bertho (Author), Daniela Brondani (Author), Eduardo Zapp (Author), Aldo Sena de Oliveira (Author), Kátia S. Calabrese (Author), Maria D. Behrens (Author), Fernando Almeida-Souza (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Carajurin is the main constituent of <i>Arrabidaea chica</i> species with reported anti-<i>Leishmania</i> activity. However, its mechanism of action has not been described. This study investigated the mechanisms of action of carajurin against promastigote forms of <i>Le...