Intestinal Na+ Loss and Volume Depletion in JAK3-Deficient Mice

• Main Authors: Anja T. Umbach (Author), Dong Luo (Author), Shefalee K. Bhavsar (Author), Zohreh Hosseinzadeh (Author), Florian Lang (Author)
• Format: Book
• Published: Karger Publishers, 2013-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: The Janus kinase 3 JAK3 participates in the signaling of immune cells. Lack of JAK3 triggers inflammatory bowel disease, which in turn has been shown to affect intestinal activity of the epithelial Na+ channel ENaC and thus colonic sodium absorption. At least in theory, inflammatory...