Inhibition of BCL11B induces downregulation of PTK7 and results in growth retardation and apoptosis in T-cell acute lymphoblastic leukemia

• Main Authors: Kehan Li (Author), Cunte Chen (Author), Rili Gao (Author), Xibao Yu (Author), Youxue Huang (Author), Zheng Chen (Author), Zhuandi Liu (Author), Shaohua Chen (Author), Gengxin Luo (Author), Xin Huang (Author), Grzegorz K. Przybylski (Author), Yangqiu Li (Author), Chengwu Zeng (Author)
• Format: Book
• Published: BMC, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive subtype of leukemia with poor prognosis, and biomarkers and novel therapeutic targets are urgently needed for this disease. Our previous studies have found that inhibition of the B-cell leukemia/lymphoma 11B (BCL11B) gene could si...