Ameliorative inhibition of sirtuin 6 by imidazole derivative triggers oxidative stress-mediated apoptosis associated with Nrf2/Keap1 signaling in non-small cell lung cancer cell lines

• Main Authors: Uma Maheswara Rao Dindi (Author), Sameer Al-Ghamdi (Author), Naif Abdurhman Alrudian (Author), Salman Bin Dayel (Author), Abdulwahab Ali Abuderman (Author), Mohammed Saad Alqahtani (Author), Nasraddin Othman Bahakim (Author), Thiyagarajan Ramesh (Author), Ravikumar Vilwanathan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Redox homeostasis is the vital regulatory system with respect to antioxidative response and detoxification. The imbalance of redox homeostasis causes oxidative stress. Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2, also called Nfe2l2)/Kelchlike ECH-associated protein 1 (Keap1) si...