Phenotypic features of dystrophin gene knockout pigs harboring a human artificial chromosome containing the entire dystrophin gene

• Main Authors: Masahito Watanabe (Author), Hitomaru Miyamoto (Author), Kazutoshi Okamoto (Author), Kazuaki Nakano (Author), Hitomi Matsunari (Author), Kanako Kazuki (Author), Koki Hasegawa (Author), Ayuko Uchikura (Author), Shuko Takayanagi (Author), Kazuhiro Umeyama (Author), Yosuke Hiramuki (Author), Elisabeth Kemter (Author), Nikolai Klymuik (Author), Mayuko Kurome (Author), Barbara Kessler (Author), Eckhard Wolf (Author), Yasuhiro Kazuki (Author), Hiroshi Nagashima (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mammalian artificial chromosomes have enabled the introduction of extremely large amounts of genetic information into animal cells in an autonomously replicating, nonintegrating format. However, the evaluation of human artificial chromosomes (HACs) as novel tools for curing intractable hereditary di...