USP7: Novel Drug Target in Cancer Therapy

• Main Authors: Zhiru Wang (Author), Wenting Kang (Author), Yinghua You (Author), Jingru Pang (Author), Hongmei Ren (Author), Zhenhe Suo (Author), Hongmin Liu (Author), Yichao Zheng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that erases ubiquitin and protects substrate protein from degradation. Full activity of USP7 requires the C-terminal Ub-like domains fold back onto the catalytic domain, allowing the remodeling of the active site to a...