Pyrazolo[4,3-c]pyridine Sulfonamides as Carbonic Anhydrase Inhibitors: Synthesis, Biological and In Silico Studies

• Main Authors: Andrea Angeli (Author), Victor Kartsev (Author), Anthi Petrou (Author), Boris Lichitsky (Author), Andrey Komogortsev (Author), Mariana Pinteala (Author), Athina Geronikaki (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Carbonic anhydrases (CAs, EC 4.2.1.1) catalyze the essential reaction of CO₂ hydration in all living organisms, being actively involved in the regulation of a plethora of patho-/physiological conditions. A series of chromene-based sulfonamides were synthesized and tested as po...