Identification of probe-quality degraders for Poly(ADP-ribose) polymerase-1 (PARP-1)

• Main Authors: Zhimin Zhang (Author), Xinyue Chang (Author), Chixiao Zhang (Author), Shenxin Zeng (Author), Meihao Liang (Author), Zhen Ma (Author), Zunyuan Wang (Author), Wenhai Huang (Author), Zhengrong Shen (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Poly(ADP-ribose) polymerase-1 (PARP-1), a critical DNA repair enzyme in the base excision repair pathway, has been pursued as an attractive cancer therapeutic target. Intervention with PARP-1 has been proved to be more sensitive to cancer cells carrying BRCA1/2 mutations. Several PARP-1 inhibitors h...