First‐in‐human phase 1 trial evaluating safety, pharmacokinetics, and pharmacodynamics of NLRP3 inflammasome inhibitor, GDC‐2394, in healthy volunteers
Abstract Inappropriate and chronic activation of the cytosolic NOD‐, LRR‐, and pyrin domain‐containing 3 (NLRP3) inflammasome, a key component of innate immunity, likely underlies several inflammatory diseases, including coronary artery disease. This first‐in‐human phase I trial evaluated safety, ph...
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Main Authors: | , , , , , , , , , , , , , , , , , , |
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Format: | Book |
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Wiley,
2023-09-01T00:00:00Z.
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A1234.567 |
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Copy 1 | Available |