Pre-Clinical Evaluation of Tenofovir and Tenofovir Alafenamide for HIV-1 Pre-Exposure Prophylaxis in Foreskin Tissue

• Main Authors: Laura Else (Author), Sujan D. Penchala (Author), Azure-Dee Pillay (Author), Thabiso B. Seiphetlo (Author), Limakatso Lebina (Author), Christian Callebaut (Author), Suks Minhas (Author), Roland Morley (Author), Tina Rashid (Author), Neil Martinson (Author), Julie Fox (Author), Saye Khoo (Author), Carolina Herrera (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: HIV-1 pre-exposure prophylaxis (PrEP) has focused predominantly on protective efficacy in receptive sex, with limited research on the dosing requirements for insertive sex. We pre-clinically assessed the ex vivo pharmacokinetic-pharmacodynamic (PK-PD) profile of tenofovir (TFV) and tenof...