A Rational Approach to Predicting Immediate Release Formulation Behavior in Multiple Gastric Motility Patterns: A Combination of a Biorelevant Apparatus, Design of Experiments, and Machine Learning

• Main Authors: Marcela Staniszewska (Author), Michał Romański (Author), Sebastian Polak (Author), Grzegorz Garbacz (Author), Justyna Dobosz (Author), Daria Myslitska (Author), Svitlana Romanova (Author), Jadwiga Paszkowska (Author), Dorota Danielak (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gastric mechanical stress often impacts drug dissolution from solid oral dosage forms, but in vitro experiments cannot recreate the substantial variability of gastric motility in a reasonable time. This study, for the first time, combines a novel dissolution apparatus with the design of experiments...