A Rational Approach to Predicting Immediate Release Formulation Behavior in Multiple Gastric Motility Patterns: A Combination of a Biorelevant Apparatus, Design of Experiments, and Machine Learning

Gastric mechanical stress often impacts drug dissolution from solid oral dosage forms, but in vitro experiments cannot recreate the substantial variability of gastric motility in a reasonable time. This study, for the first time, combines a novel dissolution apparatus with the design of experiments...

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Main Authors: Marcela Staniszewska (Author), Michał Romański (Author), Sebastian Polak (Author), Grzegorz Garbacz (Author), Justyna Dobosz (Author), Daria Myslitska (Author), Svitlana Romanova (Author), Jadwiga Paszkowska (Author), Dorota Danielak (Author)
Formato: Livro
Publicado em: MDPI AG, 2023-07-01T00:00:00Z.
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