A Rational Approach to Predicting Immediate Release Formulation Behavior in Multiple Gastric Motility Patterns: A Combination of a Biorelevant Apparatus, Design of Experiments, and Machine Learning

• Hoofdauteurs: Marcela Staniszewska (Auteur), Michał Romański (Auteur), Sebastian Polak (Auteur), Grzegorz Garbacz (Auteur), Justyna Dobosz (Auteur), Daria Myslitska (Auteur), Svitlana Romanova (Auteur), Jadwiga Paszkowska (Auteur), Dorota Danielak (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2023-07-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Gastric mechanical stress often impacts drug dissolution from solid oral dosage forms, but in vitro experiments cannot recreate the substantial variability of gastric motility in a reasonable time. This study, for the first time, combines a novel dissolution apparatus with the design of experiments...