A Rational Approach to Predicting Immediate Release Formulation Behavior in Multiple Gastric Motility Patterns: A Combination of a Biorelevant Apparatus, Design of Experiments, and Machine Learning

• Päätekijät: Marcela Staniszewska (Tekijä), Michał Romański (Tekijä), Sebastian Polak (Tekijä), Grzegorz Garbacz (Tekijä), Justyna Dobosz (Tekijä), Daria Myslitska (Tekijä), Svitlana Romanova (Tekijä), Jadwiga Paszkowska (Tekijä), Dorota Danielak (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2023-07-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Gastric mechanical stress often impacts drug dissolution from solid oral dosage forms, but in vitro experiments cannot recreate the substantial variability of gastric motility in a reasonable time. This study, for the first time, combines a novel dissolution apparatus with the design of experiments...