A patient-derived stem cell model of hereditary spastic paraplegia with SPAST mutations

A patient-derived stem cell model of hereditary spastic paraplegia with SPAST mutations

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SUMMARY Hereditary spastic paraplegia (HSP) leads to progressive gait disturbances with lower limb muscle weakness and spasticity. Mutations in SPAST are a major cause of adult-onset, autosomal-dominant HSP. Spastin, the protein encoded by SPAST, is a microtubule-severing protein that is enriched in...

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Main Authors: Greger Abrahamsen (Author), Yongjun Fan (Author), Nicholas Matigian (Author), Gautam Wali (Author), Bernadette Bellette (Author), Ratneswary Sutharsan (Author), Jyothy Raju (Author), Stephen A. Wood (Author), David Veivers (Author), Carolyn M. Sue (Author), Alan Mackay-Sim (Author)
Format: Book
Published: The Company of Biologists, 2013-03-01T00:00:00Z.
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