Heme Oxygenase-1 Reduces Sepsis-Induced Endoplasmic Reticulum Stress and Acute Lung Injury

• Main Authors: Xiaozhen Chen (Author), Yinglin Wang (Author), Xiang Xie (Author), Hongfei Chen (Author), Qiqi Zhu (Author), Zhidong Ge (Author), Hua Wei (Author), Jingshong Deng (Author), Zhengyuan Xia (Author), Qingquan Lian (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Sepsis leads to severe acute lung injury/acute respiratory distress syndrome (ALI/ARDS) that is associated with enhanced endoplasmic reticulum (ER) stress. Heme oxygenase-1 (HO-1), an ER-anchored protein, exerts antioxidant and protective functions under ALI. However, the role of HO-1 ac...