Long-term Expression of Apolipoprotein B mRNA-specific Hammerhead Ribozyme via scAAV8.2 Vector Inhibits Atherosclerosis in Mice

• Hoofdauteurs: Hersharan Nischal (Auteur), Hua Sun (Auteur), Yuchun Wang (Auteur), David A Ford (Auteur), Ying Cao (Auteur), Peng Wei (Auteur), Ba-Bie Teng (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2013-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Target substrate-specific hammerhead ribozyme cleaves the specific mRNA efficiently and results in the inhibition of gene expression. In humans, overproduction of apolipoprotein B (apoB) is positively associated with premature coronary artery diseases. The goal of this study is to demonstrate that l...