Long-term Expression of Apolipoprotein B mRNA-specific Hammerhead Ribozyme via scAAV8.2 Vector Inhibits Atherosclerosis in Mice

• Autores principales: Hersharan Nischal (Autor), Hua Sun (Autor), Yuchun Wang (Autor), David A Ford (Autor), Ying Cao (Autor), Peng Wei (Autor), Ba-Bie Teng (Autor)
• Formato: Libro
• Publicado: Elsevier, 2013-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Target substrate-specific hammerhead ribozyme cleaves the specific mRNA efficiently and results in the inhibition of gene expression. In humans, overproduction of apolipoprotein B (apoB) is positively associated with premature coronary artery diseases. The goal of this study is to demonstrate that l...