Acute pancreatitis following asparaginase treatment in pediatric acute lymphoblastic leukemia with a heterozygous SPINK1 c.194 + 2T>C intronic variant: a case report

BackgroundAsparaginase is a critical component of chemotherapy for pediatric acute lymphoblastic leukemia (ALL), but its use is often complicated by asparaginase-associated pancreatitis (AAP). Genetic predispositions, such as variants in the SPINK1 gene, have been linked to an increased risk of panc...

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Main Authors: Hua Zhou (Author), Jun Lu (Author), Tao Wang (Author), Xiaoyan Gu (Author), Xueya Li (Author), Jing Zhao (Author)
Format: Book
Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
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