Novel Regioselective Synthesis of 1,3,4,5-Tetrasubstituted Pyrazoles and Biochemical Valuation on F<sub>1</sub>F<sub>O</sub>-ATPase and Mitochondrial Permeability Transition Pore Formation

Novel Regioselective Synthesis of 1,3,4,5-Tetrasubstituted Pyrazoles and Biochemical Valuation on F<sub>1</sub>F<sub>O</sub>-ATPase and Mitochondrial Permeability Transition Pore Formation

An efficient, eco-compatible, and very cheap method for the construction of fully substituted pyrazoles (Pzs) via eliminative nitrilimine-alkene 1,3-dipolar cycloaddition (ENAC) reaction was developed in excellent yield and high regioselectivity. Enaminones and nitrilimines generated in situ were se...

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Main Authors: Vincenzo Algieri (Author), Cristina Algieri (Author), Paola Costanzo (Author), Giulia Fiorani (Author), Antonio Jiritano (Author), Fabrizio Olivito (Author), Matteo Antonio Tallarida (Author), Fabiana Trombetti (Author), Loredana Maiuolo (Author), Antonio De Nino (Author), Salvatore Nesci (Author)
Format: Book
Published: MDPI AG, 2023-02-01T00:00:00Z.
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