A Cystine-Rich Whey Supplement (Immunocal®) Delays Disease Onset and Prevents Spinal Cord Glutathione Depletion in the hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

• Glavni autori: Erika K. Ross (Autor), Aimee N. Winter (Autor), Heather M. Wilkins (Autor), Whitney A. Sumner (Autor), Nathan Duval (Autor), David Patterson (Autor), Daniel A. Linseman (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2014-12-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Depletion of the endogenous antioxidant, glutathione (GSH), underlies progression of the devastating neurodegenerative disease, amyotrophic lateral sclerosis (ALS). Thus, strategies aimed at elevating GSH may yield new therapeutics for ALS. Here, we investigated the effects of a unique non-denatured...