Cytochrome P450 3A4 suppression by epimedium and active compound kaempferol leads to synergistic anti-inflammatory effect with corticosteroid

• Main Authors: Ke Li (Author), Xiu-Hua Yu (Author), Anish R. Maskey (Author), Ibrahim Musa (Author), Zhen-Zheng Wang (Author), Victor Garcia (Author), Austin Guo (Author), Nan Yang (Author), Kamal Srivastava (Author), David Dunkin (Author), Jun-Xiong Li (Author), Longgang Guo (Author), Yung-Chi Cheng (Author), Haoliang Yuan (Author), Raj Tiwari (Author), Xiu-Min Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Cytochrome P450 (CYP) 3A4 is a major drug metabolizing enzyme for corticosteroids (CS). Epimedium has been used for asthma and variety of inflammatory conditions with or without CS. It is unknown whether epimedium has an effect on CYP 3A4 and how it interacts with CS. We sought to dete...