Epigenetic landscapes of intracranial aneurysm risk haplotypes implicate enhancer function of endothelial cells and fibroblasts in dysregulated gene expression

• Main Authors: Kerry E. Poppenberg (Author), Haley R. Zebraski (Author), Naval Avasthi (Author), Muhammad Waqas (Author), Adnan H. Siddiqui (Author), James N. Jarvis (Author), Vincent M. Tutino (Author)
• Format: Book
• Published: BMC, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Genome-wide association studies have identified many single nucleotide polymorphisms (SNPs) associated with increased risk for intracranial aneurysm (IA). However, how such variants affect gene expression within IA is poorly understood. We used publicly-available ChIP-Seq data to...