Use of physiologically‐based pharmacokinetic modeling to understand the effect of omeprazole administration on the pharmacokinetics of oral extended‐release nifedipine

• Main Authors: Ming‐Liang Tan (Author), Zongming Gao (Author), Andrew Babiskin (Author), Myong‐Jin Kim (Author), Lanyan Fang (Author), Lei Zhang (Author), Liang Zhao (Author)
• Format: Book
• Published: Wiley, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Proton pump inhibitors (PPIs) can affect the release of drugs from their dosage forms in vivo by elevating the gastric pH. Our recent clinical study has demonstrated that drug-drug interactions (DDIs) exist between a PPI, omeprazole, and nifedipine extended‐release formulations, where syste...