Effects of CYP3A4*22 polymorphism on trough concentration of tacrolimus in kidney transplantation: a systematic review and meta-analysis

Purpose: Tacrolimus (Tac) is a widely used immunosuppressive agent in kidney transplantation. Cytochrome P450 (CYP), especially CYP3A4 enzymes are responsible for the metabolism of drugs. However, the correlation between plasma Tac concentration and CYP3A4*22 gene variants is controversial. This met...

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Main Authors: Jung Sun Kim (Author), Sunyoung Shim (Author), Jeong Yee (Author), Kyung Hee Choi (Author), Hye Sun Gwak (Author)
Format: Book
Published: Frontiers Media S.A., 2023-07-01T00:00:00Z.
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3rd Floor Main Library

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