Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug-Drug Interaction and Associated Biomarker Levels in Healthy Volunteers

• Main Authors: Sook Wah Yee (Author), Marilyn M. Giacomini (Author), Hong Shen (Author), W. Griffith Humphreys (Author), Howard Horng (Author), William Brian (Author), Yurong Lai (Author), Deanna L. Kroetz (Author), Kathleen M. Giacomini (Author)
• Format: Book
• Published: Wiley, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Understanding transporter‐mediated drug-drug interactions is an integral part of risk assessment in drug development. Recent studies support the use of hexadecanedioate (HDA), tetradecanedioate (TDA), coproporphyrin (CP)‐I, and CP‐III as clinical biomarkers for evaluating organic anion‐transporting...