Phosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in epithelial ovarian cancer

• Main Authors: Rebecca M. Borneman (Author), Elaine Gavin (Author), Alla Musiyenko (Author), Wito Richter (Author), Kevin J. Lee (Author), David K. Crossman (Author), Joel F. Andrews (Author), Annelise M. Wilhite (Author), Steven McClellan (Author), Ileana Aragon (Author), Antonio B. Ward (Author), Xi Chen (Author), Adam B. Keeton (Author), Kristy Berry (Author), Gary A. Piazza (Author), Jennifer M. Scalici (Author), Luciana Madeira da Silva (Author)
• Format: Book
• Published: BMC, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract A leading theory for ovarian carcinogenesis proposes that inflammation associated with incessant ovulation is a driver of oncogenesis. Consistent with this theory, nonsteroidal anti-inflammatory drugs (NSAIDs) exert promising chemopreventive activity for ovarian cancer. Unfortunately, toxic...