Development of a novel intramuscular liposomal injection for advanced meloxicam delivery: Preparation, characterization, in vivo pharmacokinetics, pharmacodynamics, and pain assessment in an orthopedic pain model

• Main Authors: Pierre A. Hanna (Author), Hatim A. Al-Abbadi (Author), Mohamed A. Hashem (Author), Aziza E. Mostafa (Author), Yasmina K. Mahmoud (Author), Eman A. Ahmed (Author), Ibrahim M. Hegab (Author), Ibrahim E. Helal (Author), Mahmoud F. Ahmed (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pain produces several physiological, and degenerative complications. This study aimed to formulate meloxicam (MLX) in liposomes to increase solubility and deliver MLX in a controlled manner to overcome its poor aqueous solubility and relatively short t1/2 problems. Liposomes were prepared by thin fi...