Pharmacokinetics and Pharmacodynamics of (S)-Ketoprofen Co-Administered with Caffeine: A Preclinical Study in Arthritic Rats

• المؤلفون الرئيسيون: Raúl Medina-López (مؤلف), Nancy Vara-Gama (مؤلف), Olivia Soria-Arteche (مؤلف), Luis A. Moreno-Rocha (مؤلف), Francisco J. López-Muñoz (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2018-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The purpose of the present study was to determine whether caffeine modifies the pharmacokinetics and pharmacodynamics of (S)-ketoprofen following oral administration in a gout-type pain model. 3.2 mg/kg of (S)-ketoprofen alone and combined with 17.8 mg/kg of caffeine were administered to Wistar rats...