The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway

• Main Authors: Geni Ye (Author), Maohua Huang (Author), Yong Li (Author), Jie Ouyang (Author), Minfeng Chen (Author), Qing Wen (Author), Xiaobo Li (Author), Huhu Zeng (Author), Pei Long (Author), Zepei Fan (Author), Junqiang Yin (Author), Wencai Ye (Author), Dongmei Zhang (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteosarcoma is a kind of bone tumor with highly proliferative and invasive properties, a high incidence of pulmonary metastasis and a poor prognosis. Chemotherapy is the mainstay of treatment for osteosarcoma. Currently, there are no molecular targeted drugs approved for osteosarcoma treatment, par...