Biosynthesis of antibiotic chuangxinmycin from Actinoplanes tsinanensis

• Main Authors: Yuanyuan Shi (Author), Zhibo Jiang (Author), Xingxing Li (Author), Lijie Zuo (Author), Xuan Lei (Author), Liyan Yu (Author), Linzhuan Wu (Author), Jiandong Jiang (Author), Bin Hong (Author)
• Format: Book
• Published: Elsevier, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chuangxinmycin is an antibiotic isolated from Actinoplanes tsinanensis CPCC 200056 in the 1970s with a novel indole-dihydrothiopyran heterocyclic skeleton. Chuangxinmycin showed in vitro antibacterial activity and in vivo efficacy in mouse infection models as well as preliminary clinical trials. But...