Avoiding the Pitfalls of siRNA Delivery to the Retinal Pigment Epithelium with Physiologically Relevant Cell Models

• Main Authors: Eva Ramsay (Author), Manuela Raviña (Author), Sanjay Sarkhel (Author), Sarah Hehir (Author), Neil R. Cameron (Author), Tanja Ilmarinen (Author), Heli Skottman (Author), Jørgen Kjems (Author), Arto Urtti (Author), Marika Ruponen (Author), Astrid Subrizi (Author)
• Format: Book
• Published: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammation is involved in the pathogenesis of several age-related ocular diseases, such as macular degeneration (AMD), diabetic retinopathy, and glaucoma. The delivery of anti-inflammatory siRNA to the retinal pigment epithelium (RPE) may become a promising therapeutic option for the treatment of...