Circular siRNAs for Reducing Off-Target Effects and Enhancing Long-Term Gene Silencing in Cells and Mice

• Main Authors: Liangliang Zhang (Author), Duanwei Liang (Author), Changmai Chen (Author), Yuan Wang (Author), Gubu Amu (Author), Jiali Yang (Author), Lijia Yu (Author), Ivan J. Dmochowski (Author), Xinjing Tang (Author)
• Format: Book
• Published: Elsevier, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Circular non-coding RNAs are found to play important roles in biology but are still relatively unexplored as a structural motif for chemically regulating gene function. Here, we investigated whether small interfering RNA (siRNA) with a circular structure can circumvent off-target gene silencing, a p...