Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography.

Chagas disease, caused by Trypanosoma cruzi, affects millions of people in South America and no satisfactory therapy exists, especially for its life threatening chronic phase. We targeted the Proline Racemase of T. cruzi, which is present in all stages of the parasite life cycle, to discover new inh...

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Main Authors: Patricia de Aguiar Amaral (Author), Delphine Autheman (Author), Guilherme Dias de Melo (Author), Nicolas Gouault (Author), Jean-François Cupif (Author), Sophie Goyard (Author), Patricia Dutra (Author), Nicolas Coatnoan (Author), Alain Cosson (Author), Damien Monet (Author), Frederick Saul (Author), Ahmed Haouz (Author), Philippe Uriac (Author), Arnaud Blondel (Author), Paola Minoprio (Author)
Format: Book
Published: Public Library of Science (PLoS), 2018-10-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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