Novel Auger-Electron-Emitting ¹⁹¹Pt-Labeled Pyrrole-Imidazole Polyamide Targeting MYCN Increases Cytotoxicity and Cytosolic dsDNA Granules in MYCN-Amplified Neuroblastoma

• المؤلفون الرئيسيون: Honoka Obata (مؤلف), Atsushi B. Tsuji (مؤلف), Hitomi Sudo (مؤلف), Aya Sugyo (مؤلف), Kaori Hashiya (مؤلف), Hayato Ikeda (مؤلف), Masatoshi Itoh (مؤلف), Katsuyuki Minegishi (مؤلف), Kotaro Nagatsu (مؤلف), Mikako Ogawa (مؤلف), Toshikazu Bando (مؤلف), Hiroshi Sugiyama (مؤلف), Ming-Rong Zhang (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2023-10-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Auger electrons can cause nanoscale physiochemical damage to specific DNA sites that play a key role in cancer cell survival. Radio-Pt is a promising Auger-electron source for damaging DNA efficiently because of its ability to bind to DNA. Considering that the cancer genome is maintained under abnor...