Novel Auger-Electron-Emitting ¹⁹¹Pt-Labeled Pyrrole-Imidazole Polyamide Targeting MYCN Increases Cytotoxicity and Cytosolic dsDNA Granules in MYCN-Amplified Neuroblastoma

• Main Authors: Honoka Obata (Author), Atsushi B. Tsuji (Author), Hitomi Sudo (Author), Aya Sugyo (Author), Kaori Hashiya (Author), Hayato Ikeda (Author), Masatoshi Itoh (Author), Katsuyuki Minegishi (Author), Kotaro Nagatsu (Author), Mikako Ogawa (Author), Toshikazu Bando (Author), Hiroshi Sugiyama (Author), Ming-Rong Zhang (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Auger electrons can cause nanoscale physiochemical damage to specific DNA sites that play a key role in cancer cell survival. Radio-Pt is a promising Auger-electron source for damaging DNA efficiently because of its ability to bind to DNA. Considering that the cancer genome is maintained under abnor...