Casein Kinase 1δ/ε Inhibitor, PF670462 Attenuates the Fibrogenic Effects of Transforming Growth Factor-β in Pulmonary Fibrosis

• Main Authors: Christine R. Keenan (Author), Shenna Y. Langenbach (Author), Fernando Jativa (Author), Trudi Harris (Author), Meina Li (Author), Qianyu Chen (Author), Yuxiu Xia (Author), Bryan Gao (Author), Michael J. Schuliga (Author), Jade Jaffar (Author), Danica Prodanovic (Author), Yan Tu (Author), Asres Berhan (Author), Peter V. S. Lee (Author), Glen P. Westall (Author), Alastair G. Stewart (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transforming growth factor-beta (TGF-β) is a major mediator of fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). However, therapeutic global inhibition of TGF-β is limited by unwanted immunosuppression and mitral valve defects. We performed an extensive literature search to uncover a...