Physiologically based pharmacokinetic modeling for development and applications of a virtual celiac disease population using felodipine as a model drug

• Main Authors: Farzaneh Salem (Author), Ali Nimavardi (Author), Jennypher Mudunuru (Author), Debra Tompson (Author), Jackie Bloomer (Author), David B. Turner (Author), Kunal S. Taskar (Author)
• Format: Book
• Published: Wiley, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract In celiac disease (CeD), gastrointestinal CYP3A4 abundance and morphology is affected by the severity of disease. Therefore, exposure to CYP3A4 substrates and extent of drug interactions is altered. A physiologically‐based pharmacokinetic (PBPK) population for different severities of CeD wa...