Killing of Staphylococci by θ-Defensins Involves Membrane Impairment and Activation of Autolytic Enzymes

• Váldodahkkit: Miriam Wilmes (Dahkki), Marina Stockem (Dahkki), Gabriele Bierbaum (Dahkki), Martin Schlag (Dahkki), Friedrich Götz (Dahkki), Dat Q. Tran (Dahkki), Justin B. Schaal (Dahkki), André J. Ouellette (Dahkki), Michael E. Selsted (Dahkki), Hans-Georg Sahl (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2014-11-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

θ-Defensins are cyclic antimicrobial peptides expressed in leukocytes of Old world monkeys. To get insight into their antibacterial mode of action, we studied the activity of RTDs (rhesus macaque θ-defensins) against staphylococci. We found that in contrast to other defensins, RTDs do not interfere...