Inhibition of Gastric Tumor Cell Growth Using Seed-targeting LNA as Specific, Long-lasting MicroRNA Inhibitors

• Main Authors: Cathy Staedel (Author), Christine Varon (Author), Phu Hung Nguyen (Author), Brune Vialet (Author), Lucie Chambonnier (Author), Benoît Rousseau (Author), Isabelle Soubeyran (Author), Serge Evrard (Author), Franck Couillaud (Author), Fabien Darfeuille (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MicroRNAs regulate eukaryotic gene expression upon pairing onto target mRNAs. This targeting is influenced by the complementarity between the microRNA "seed" sequence at its 5' end and the seed-matching sequences in the mRNA. Here, we assess the efficiency and specificity of 8-mer loc...