Preparation and Characterization of Amino Acids-Based Trimethoprim Salts
Trimethoprim (TMP) is a dihydrofolate reductase (DHFR) inhibitor which prevents the conversion of dihydrofolic acid into tetrahydrofolic acid, resulting in the depletion of the latter and leading to bacterial death. Oral bioavailability of TMP is hindered by both its low solubility and low permeabil...
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Format: | Book |
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MDPI AG,
2012-02-01T00:00:00Z.
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A1234.567 |
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